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Edited by Reinhart Grundmann, ISBN 978-953-307-523-5, Hard cover, 222 pages, Publisher: InTech, Published: July 27, 2011 under CC BY-NC-SA 3.0 license, in subject Cardiology and Cardiovascular Medicine
This book considers mainly etiology, pathogenesis, and pathophysiology of aortic aneurysms (AA) and aneurysm rupture and addresses anyone engaged in treatment and prevention of AA. Multiple factors are implicated in AA pathogenesis, and are outlined here in detail by a team of specialist researchers. Initial pathological events in AA involve recruitment and infiltration of leukocytes into the aortic adventitia and media, which are associated with the production of inflammatory cytokines, chemokine, and reactive oxygen species. AA development is characterized by elastin fragmentation. As the aorta dilates due to loss of elastin and attenuation of the media, the arterial wall thickens as a result of remodeling. Collagen synthesis increases during the early stages of aneurysm formation, suggesting a repair process, but resulting in a less distensible vessel. Proteases identified in excess in AA and other aortic diseases include matrix metalloproteinases (MMPs), cathepsins, chymase and others. The elucidation of these issues will identify new targets for prophylactic and therapeutic intervention. More Info (Intech-Website)
Diagnosis, Screening and Treatment of Abdominal, Thoracoabdominal and Thoracic Aortic Aneurysms
Edited by R.T. Grundmann, ISBN 978-953-307-466-5, Hard cover, 414 pages, Publisher: InTech, Published: September 12, 2011 under CC BY-NC-SA 3.0 license, in subject Cardiology and Cardiovascular Medicine
This book considers mainly diagnosis, screening, surveillance and treatment of abdominal, thoracoabdominal and thoracic aortic aneurysms. It addresses vascular and cardiothoracic surgeons and interventional radiologists, but also anyone engaged in vascular medicine. The high mortality of ruptured aneurysms certainly favors the recommendation of prophylactic repair of asymptomatic aortic aneurysms (AA) and therewith a generous screening. However, the comorbidities of these patients and their age have to be kept in mind if the efficacy and cost effectiveness of screening and prophylactic surgery should not be overestimated. The treatment recommendations which will be outlined here, have to regard on the one hand the natural course of the disease, the risk of rupture, and the life expectancy of the patient, and on the other hand the morbidity and mortality of the prophylactic surgical intervention. The book describes perioperative mortality after endovascular and open repair of AA, long-term outcome after repair, and the cost-effectiveness of treatment. More Info (Intech-Website)
Edited by Reinhart T. Grundmann, ISBN 978-953-307-524-2, Hard cover, 208 pages, Publisher: InTech, Published: October 05, 2011 under CC BY 3.0 license, in subject Surgery
This book considers diagnosis and treatment of abdominal and thoracic aortic aneurysms. It addresses vascular and cardiothoracic surgeons and interventional radiologists, but also anyone engaged in vascular medicine. The book focuses amongst other things on operations in the ascending aorta and the aortic arch. Surgical procedures in this area have received increasing attention in the last few years and have been subjected to several modifications. Especially the development of interventional radiological endovascular techniques that reduce the invasive nature of surgery as well as complication rates led to rapid advancements. Thoracoabdominal aortic aneurysm (TAAA) repair still remains a challenging operation since it necessitates extended exposure of the aorta and reimplantation of the vital aortic branches. Among possible postoperative complications, spinal cord injury (SCI) seems one of the most formidable morbidities. Strategies for TAAA repair and the best and most reasonable approach to prevent SCI after TAAA repair are presented. More Info (Intech-Website)
Prof. Dr. R.T. Grundmann
Aus Chirurgische Allgemeine (CHAZ) 2011; 12:187-192
Bei dem Namen "Larrey" denken Chirurgen zunächst an die Larrey’sche Spalte, die sehr seltene linksseitige parasternale Zwerchfellhernie und den Larrey’schen Punkt (linksseitigerWinkel zwischen Proc. xyphoideus und sternalem Rippenbogenansatz) zur Perikardpunktion bei Perikardtamponade. Der medizinhistorisch Interessierte assoziiert auch den Chirurgen in Napoleons Diensten.
Kaum vorstellbar ist es aber dem DRG-geplagten, Regressforderungen und ökonomischem Druck ausgesetzten Chirurgen, dass es Zeiten gab, in denen der Nachwuchsmangel oder die Attraktivität des Fachs kein Thema waren – sondern im Gegenteil Zeiten, die einem Chirurgen ein Denkmal setzten ...!
Dies will die vorliegende Arbeit verdeutlichen. Dabei soll weniger auf neuere Sekundärliteratur zurückgegriffen werden, wie etwa die Aufsätze von Dible , Richardson  oder Skandalakis et al. , sondern es sollen vor allem die Zeitgenossen und unmittelbaren Nachfahren selbst zu Wort kommen [4–6].
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Dominique-Jean Larrey, „revolutionärer“ Chirurg in Napoleons Diensten